Signal Transduction Reagents and Kits
Enzo Life Sciences Salubrinal (5mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Appearance: White to off-white powder. Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Abcam Glucose-6-Phosphate Assay Kit (Colorimetric)
Glucose-6-Phosphate Assay Kit (Colorimetric)
The product is subject to the following: Abcam Restricted Use Statement
Aat Bioquest Cal-590™ AM | 5x50ug
Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Rhod-2 is most commonly used among the red fluorescent calcium indicators. However, Rhod-2 AM is only moderately fluorescent in live cells upon esterase hydrolysis, and has very small cellular calcium responses. Cal-590™ has been developed to improve Rhod-2 cell loading and calcium response while maintaining the spectral wavelength of Rhod-2, making it compatible with TRITC/Cy3 filter set. In CHO and HEK cells Cal-590™ AM has cellular calcium response that is much more sensitive than Rhod-2 AM.
Meso Scale Discovery Phospho-STAT3 (Tyr705) Kit, 96-well plate, 25 plates, detects STAT3 pTyr705, suitable for human, mouse, rat samples, compatible with various MSD instruments
The MESO SCALE DISCOVERY Phospho-STAT3 (Tyr705) Kit is designed as a rapid and convenient assay for the detection of STAT3 phosphorylated at tyrosine 705. The kit is suitable for research applications focused on phosphoproteins and intracellular signaling across various species, including human, mouse, and rat. Utilizing a 96-well plate format, it enables efficient processing of samples with high-throughput compatibility.
- Detects STAT3 phosphorylated at Tyr705, a crucial activation site.
- Validated for use with human, mouse, and rat samples.
- Compatible with multiple MSD instruments.
- Contains all essential reagents for accurate results.
- Includes comprehensive kit contents such as SULFO-TAG antibody and various buffers.
- Intended for research use only.
- Stored as multi-component modules.
Carnabio Usa Inc CK1G1(CSNK1G1)/5UG/FULL-LENGTH
CK11(CSNK1G1), Full-length, Wild type, Amino Acid 1-422, NP_071331.2, Expressed in Insect (sf21); 5microg
Carnabio Usa Inc CK2A1/B(CSNK2A1/B)/10UG/FULL-L
CK2a1/b(CSNK2A1/B), Full-length(CK2a1), Wild type, Amino Acid 1-391(CK2a1), 1-215(CK2b), NP_001886.1(CK2a1), NP_001311.3(Ck2b1), Expressed in Insect (sf21); 10microg
Enzo Life Sciences Lysophosphatidic acid (25mg). CAS: 325465-93-8
Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Purity: ≥98% (TLC). Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Long Term Storage: -20°C.
Enzo Life Sciences 8-Bromo-cGMP (10mg). CAS: 51116-01-9
A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets. Purity: ≥96% (HPLC). Solubility: Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol. Long Term Storage: -20°C.
Medchemexpress LLC Allocryptopine | 485-91-6 | 99.7% | 369.41 g/mol | C21H23NO5 | 10 MG
Allocryptopine is a dibenzazecine alkaloid (C21H23NO5, MW 369.41 g/mol) used as a potassium-channel inhibitor in cardiovascular and ion-channel research. Supplied in small research pack sizes with high reported purity, the compound is intended for in vitro and other laboratory applications as a research reagent.
- Chemical formula: C21H23NO5
- Molecular weight: 369.41 g/mol
- CAS number: 485-91-6
- Purity: 99.7%
- Target: Potassium channel inhibitor (hERG-related activity)
- Intended use: Research use only
- Typical pack size: 10 MG
Enzo Life Sciences SB203580, (1mg), CAS Number: 152121-47-6
Protein kinase inhibitor. Cell permeable, specific inhibitor of p38 (SAPK2a). Inhibits p38 MAPK stimulation of MAPKAPK2 (IC.The concentrations of SB203580 required to block Akt phosphorylation (IC50= 3-5µM) are only approximately 10-fold higher than those required to inhibit p38 MAP kinase (IC50=0.3-0.5µM). These data define a new activity for this drug and suggest that extreme caution should be used when interpreting data when SB203580 has been used at concentrations above 1-2µM. Non-specific effects include inhibition of COX-1 and -2. Enhances clonal growth of skin epithelial progenitor cells and stimulates neural stem cell proliferation. Alternative Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole. Formula: C21H16N3FOS. MW: 377.4. CAS Number: 152121-47-6. Purity: ≥97% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO (50mg/ml). Long Term Storage: -20°C
Medchemexpress LLC Uk122 | 940290-58-4 | 99.9% | 291.30 g/mol | C17H13N3O2 | 5 MG
A selective small-molecule inhibitor of urokinase-type plasminogen activator (uPA) for biochemical and cellular research into protease-mediated processes such as cancer cell migration and invasion. It is a 4-oxazolidinone analogue with reported uPA inhibition (IC50 0.2 μM). Supplied as a research reagent, not for human or veterinary use.
- Selective uPA inhibition with IC50 of 0.2 μM.
- 4-oxazolidinone analogue suitable for mechanistic studies.
- High purity (~99.9%) for reproducible biochemical assays.
- Small-molecule format compatible with cell-based and enzymatic assays.
- Available in small research quantities for laboratory use.
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan United States Pharmacopeia (USP) Reference Standard | 139264-17-8 | MFCD00871503 | 200MG
Zolmitriptan United States Pharmacopeia (USP) Reference Standard | Mol Wt: 287.36 | 139264-17-8 | MFCD00871503 | 200MG
Creative Biomart Alglucosidase alfa, Recombinant Human enzyme acid alpha-glucosidase (GAA)
The product consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. The product is produced by recombinant DNA technology in a Chinese hamster ovary cell line. The product degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages of lysosomal glycogen. Structurally, the product is a glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates.
Echelon Biosciences Research Labs LINOLENOYL LPA 10 mg
Linolenoyl LPA, 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Selleck Chemical LLC SB202190 (FHPI) 25mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.